SCD: stearoyl-CoA desaturase

All genes, All MitoCarta3.0 genes, FAQ

Human synonymsSCD | FADS5|MSTP008|SCD1|SCDOS|hSCD1 | GeneID:6319 | ENSG00000099194 | O00767
Mouse orthologScd2 | Mir5114|Scd-|Scd-2|mir-5114|swty | GeneID:20250 | ENSMUSG00000025203 | P13011

MoothaLab Resources
Tissue Atlas Coexpression human GTEx RNA, mouse GNFv3 RNA, mouse protein
CCLE cell lines CRISPR-codependency, RNA-seq coexpression, RNA-microarray, CRISPR-vs-RNA-seq
Sequence Alignment (MitoCarta only) all_BBH, selected_BBH

MitoCarta3.0
In MitoCarta3.0?0
EvidenceRickettsial homolog, mito protein domain
MitoPathway
Sub-Mito Localization
MS/MS tissues
MitoCarta2.0 FDR0.578
MitoCarta2.0 TrainingTnon_mito
TargetP_v1 MTS Confidence
MitoDomainSharedDomain
Yeast HomologNoMitoHomolog
Rickettsia HomologHomolog
GeneAtlas Coexpression N50 2
PGC Induction
MSMS score
MSMS intensitycerebrum:, cerebellum:, brainstem:, spinalcord:, kidney:, liver:, heart:, muscle:, adipose:, sm_intestine:, lg_intestine:, stomach:, placenta:, testis:
MSMS unique peps
Curator notes

Miscellaneous features
HPA Main Location (2020)Endoplasmic reticulum (Enhanced)
PFAM domains (2022)0
CRISPR guides

Mootha Lab CRISPR Screen Results
Glu/Gal Death Screen (2016)not strongly enriched in Gal/Glu dead cells (fdr=1)
O2 Screen Summary (2020)not selectively essential in 1% vs 21% oxygen (fdr=1)
1%O2_vs_21%O2.day15.score (2020)0
21%O2.day15_vs_day0.score (2020)-1.8
Chemical Genetics Zscore (To 2019)DMSO:-9.3 (fdr=0); Met:-4.7 (fdr=0); Pier:-7.3 (fdr=0); Anti:-6.5 (fdr=0); Oligo:-4.6 (fdr=0.0001); AO:-3.7 (fdr=0.0019); EtBr:-6.8 (fdr=0); CAP:-6.4 (fdr=0);
TMRM Oligo Zscore (unpublished)-2

Refseq Protein Isoforms
Species mRNA ProteinID Len (AA) TargetP v1.0 TargetP v2.0 TPpred2 MitoFates Mouse Best TMHMM # Helices TMHMM Topology
humanNM_005063NP_005054 359no pred (conf=1)noTPnoMTS (score=0.92)4i71-93o98-120i217-239o249-271i
mouseNM_009128NP_033154 358no pred (conf=2)noTPnoMTS (score=0.83)4i70-92o102-124i216-235o250-272i