| Human synonyms | AKR7A2 | AFAR|AFAR1|AFB1-AR1|AKR7 | GeneID:8574 | ENSG00000053371 | O43488 |
| Mouse ortholog | Akr7a5 | 0610025K21Rik|A|Afar|Afar1|Akr7a2 | GeneID:110198 | ENSMUSG00000028743 | Q8CG76 |
| Tissue Atlas Coexpression | human GTEx RNA, mouse GNFv3 RNA, mouse protein |
| CCLE cell lines | CRISPR-codependency, RNA-seq coexpression, RNA-microarray, CRISPR-vs-RNA-seq |
| Sequence Alignment (MitoCarta only) | all_BBH, selected_BBH |
| In MitoCarta3.0? | MitoCarta3.0 |
| Evidence | APEX_matrix, targetP signal, coexpression, MS/MS++ |
| MitoPathway | Metabolism > Amino acid metabolism > GABA metabolism | Metabolism > Detoxification > Xenobiotic metabolism |
| Sub-Mito Localization | Matrix |
| MS/MS tissues | all 14 |
| MitoCarta2.0 FDR | 0.013 |
| MitoCarta2.0 Training | Tmito |
| TargetP_v1 MTS Confidence | 2 |
| MitoDomain | NonMitoDomain |
| Yeast Homolog | NoMitoHomolog |
| Rickettsia Homolog | NoHomolog |
| GeneAtlas Coexpression N50 | 12 |
| PGC Induction | |
| MSMS score | 50-75pure |
| MSMS intensity | cerebrum:8.2, cerebellum:8.1, brainstem:8.6, spinalcord:8.1, kidney:10, liver:9.3, heart:8.6, muscle:8, adipose:8.8, sm_intestine:8.7, lg_intestine:9, stomach:8.1, placenta:8.8, testis:9 |
| MSMS unique peps | 22 |
| Curator notes | MitoPath:though. localize Golgi, succininc semialdehyde redox PMID: 25215496 (Hardik, Shayan, Connie) |
| HPA Main Location (2020) | Cytosol (Supported) |
| PFAM domains (2022) | Aldo_ket_red |
| CRISPR guides |
| Glu/Gal Death Screen (2016) | not strongly enriched in Gal/Glu dead cells (fdr=1) |
| O2 Screen Summary (2020) | not selectively essential in 1% vs 21% oxygen (fdr=1) |
| 1%O2_vs_21%O2.day15.score (2020) | 0 |
| 21%O2.day15_vs_day0.score (2020) | 0 |
| Chemical Genetics Zscore (To 2019) | |
| TMRM Oligo Zscore (unpublished) | 0.1 |
| Species | mRNA | ProteinID | Len (AA) | TargetP v1.0 | TargetP v2.0 | TPpred2 | MitoFates | Mouse Best | TMHMM # Helices | TMHMM Topology |
|---|---|---|---|---|---|---|---|---|---|---|
| human | NM_003689 | NP_003680 | 359 | MTS (conf=2 len=70) | MTS (score=0.7; len=51) | MTS (score=0.94, len=35) | MTS (len=39) | 0 | o | |
| mouse | NM_025337 | NP_079613 | 367 | MTS (conf=1 len=24) | MTS (score=0.85; len=59) | MTS (score=0.95, len=35) | MTS (len=39) | 29 | 0 | o |
