PDCD5: programmed cell death 5

All genes, All MitoCarta3.0 genes, FAQ

Human synonymsPDCD5 | TFAR19 | GeneID:9141 | ENSG00000105185 | O14737
Mouse orthologPdcd5 | 2200003D22Rik|AA408513|Tfar|Tfar19 | GeneID:56330 | ENSMUSG00000030417 | P56812

MoothaLab Resources
Tissue Atlas Coexpression human GTEx RNA, mouse GNFv3 RNA, mouse protein
CCLE cell lines CRISPR-codependency, RNA-seq coexpression, RNA-microarray, CRISPR-vs-RNA-seq
Sequence Alignment (MitoCarta only) all_BBH, selected_BBH

MitoCarta3.0
In MitoCarta3.0?0
EvidenceMS/MS
MitoPathway
Sub-Mito Localization
MS/MS tissuesbrainstem, spinalcord
MitoCarta2.0 FDR0.53
MitoCarta2.0 TrainingTnon_mito
TargetP_v1 MTS Confidence
MitoDomainNA
Yeast HomologNoMitoHomolog
Rickettsia HomologNoHomolog
GeneAtlas Coexpression N50 NA
PGC Induction
MSMS score25-50ambig
MSMS intensitycerebrum:, cerebellum:, brainstem:7.3, spinalcord:7.1, kidney:, liver:, heart:, muscle:, adipose:, sm_intestine:, lg_intestine:, stomach:, placenta:, testis:
MSMS unique peps5
Curator notes

Miscellaneous features
HPA Main Location (2020)Cytosol (Approved)
PFAM domains (2022)dsDNA_bind
CRISPR guides

Mootha Lab CRISPR Screen Results
Glu/Gal Death Screen (2016)not strongly enriched in Gal/Glu dead cells (fdr=1)
O2 Screen Summary (2020)not selectively essential in 1% vs 21% oxygen (fdr=1)
1%O2_vs_21%O2.day15.score (2020)0
21%O2.day15_vs_day0.score (2020)-1.2
Chemical Genetics Zscore (To 2019)DMSO:-2.3 (fdr=0.0969); Met:-2.4 (fdr=0.0986); Pier:-2.6 (fdr=0.0471); CAP:-2.5 (fdr=0.0663);
TMRM Oligo Zscore (unpublished)-0.2

Refseq Protein Isoforms
Species mRNA ProteinID Len (AA) TargetP v1.0 TargetP v2.0 TPpred2 MitoFates Mouse Best TMHMM # Helices TMHMM Topology
mouseNM_019746NP_062720 126no pred (conf=1)noTPnoMTS (score=1)0o
humanNM_004708NP_004699 125no pred (conf=1)noTPnoMTS (score=1)0o