| Human synonyms | GPX4 | GPx-4|GSHPx-4|MCSP|PHGPx|SMDS|snGPx|snPHGPx | GeneID:2879 | ENSG00000167468 | P36969 |
| Mouse ortholog | Gpx4 | GPx-4|GSHPx-4|PHG|PHGPx|mtPHG|mtPHGPx|sn|snGPx | GeneID:625249 | ENSMUSG00000075706 | Q91XR9 |
| Tissue Atlas Coexpression | human GTEx RNA, mouse GNFv3 RNA, mouse protein |
| CCLE cell lines | CRISPR-codependency, RNA-seq coexpression, RNA-microarray, CRISPR-vs-RNA-seq |
| Sequence Alignment (MitoCarta only) | all_BBH, selected_BBH |
| In MitoCarta3.0? | MitoCarta3.0 |
| Evidence | literature, mito protein domain |
| MitoPathway | Metabolism > Detoxification > ROS and glutathione metabolism | Metabolism > Detoxification > Selenoproteins |
| Sub-Mito Localization | MIM |
| MS/MS tissues | all 14 |
| MitoCarta2.0 FDR | 0.436 |
| MitoCarta2.0 Training | Tmito |
| TargetP_v1 MTS Confidence | |
| MitoDomain | SharedDomain |
| Yeast Homolog | HomologMitoLowConf |
| Rickettsia Homolog | NoHomolog |
| GeneAtlas Coexpression N50 | NA |
| PGC Induction | |
| MSMS score | 50-75crude |
| MSMS intensity | cerebrum:8.9, cerebellum:8.6, brainstem:9.1, spinalcord:8.5, kidney:8.2, liver:7.5, heart:8, muscle:7.8, adipose:8.8, sm_intestine:8, lg_intestine:7.8, stomach:8.1, placenta:8.3, testis:10.7 |
| MSMS unique peps | 17 |
| Curator notes | MitoPath:Definitely mito (Mary, Rohit) |
| HPA Main Location (2020) | Mitochondria;Nucleoplasm (Supported) |
| PFAM domains (2022) | GSHPx |
| CRISPR guides |
| Glu/Gal Death Screen (2016) | not strongly enriched in Gal/Glu dead cells (fdr=1) |
| O2 Screen Summary (2020) | not selectively essential in 1% vs 21% oxygen (fdr=1) |
| 1%O2_vs_21%O2.day15.score (2020) | -0.8 |
| 21%O2.day15_vs_day0.score (2020) | -2 |
| Chemical Genetics Zscore (To 2019) | Pier:-2.6 (fdr=0.0484); Anti:-5.1 (fdr=0); Oligo:-6.7 (fdr=0); AO:-7.7 (fdr=0); EtBr:-10.4 (fdr=0); |
| TMRM Oligo Zscore (unpublished) | 2 |
| Species | mRNA | ProteinID | Len (AA) | TargetP v1.0 | TargetP v2.0 | TPpred2 | MitoFates | Mouse Best | TMHMM # Helices | TMHMM Topology |
|---|---|---|---|---|---|---|---|---|---|---|
| mouse | NM_008162 | NP_032188 | 197 | S (conf=4) | SP | noMTS (score=0.89) | 0 | o | ||
| human | NM_001039848 | NP_001034937 | 234 | no pred (conf=3) | noTP | noMTS (score=0.92) | 0 | o | ||
| human | NM_001039847 | NP_001034936 | 227 | S (conf=3) | SP | noMTS (score=0.9) | 0 | o | ||
| mouse | NM_001037741 | NP_001032830 | 253 | no pred (conf=3) | noTP | noMTS (score=0.96) | 0 | o | ||
| human | NM_002085 | NP_002076 | 197 | S (conf=3) | SP | noMTS (score=0.9) | 0 | o |
