Publication:
Uddin, M. M., N. Q. Nguyen, B. Yu, J. Brody, A. Pampana, T. Nakao, M. Fornage, J. Bressler, N. Sotoodehnia, J. Weinstock, M. Honigberg, D. Nachun, R. Bhattacharya, G. Griffin, V. Chander, R. Gibbs, J. Rotter, C. Liu, A. Baccarelli, D. Chasman, E. Whitsel, D. Kiel, J. Murabito, E. Boerwinkle, B. Ebert, S. Jaiswal, J. Floyd, A. Bick, C. Ballantyne, B. Psaty, P. Natarajan and K. Conneely (2022). "Clonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease." Nature Portfolio. https://www.researchsquare.com/article/rs-1463822/v1

Summary statistics includes multi-ancestry meta-analysis of overall CHIP (clonal hematopoiesis of indeterminate potential), DNMT3A, TET2 and expanded CHIP EWAS results from 582 Cardiovascular Health Study (CHS) participants (280 African-ancestry and 302 European-ancestry participants).

1. CHS_OverallCHIP_EWAS_2022.txt.gz
2. CHS_DNMT3A_CHIP_EWAS_2022.txt.gz
3. CHS_TET2_CHIP_EWAS_2022.txt.gz
4. CHS_expandedCHIP_EWAS_2022.txt.gz

Column headers:
# MarkerName      - CpG IDs from Illumina Infinium Methylation450K array
# Freq1       - weighted average of methylation level (on scale 0-1, where '0' indicates fully unmethylated CpG and '1' indicates full methylation) across all studies
# FreqSE      - corresponding standard error for methylation level estimate
# MinFreq     - minimum methylation level across all studies
# MaxFreq     - maximum methylation level across all studies
# Effect      - overall estimated effect size
# StdErr      - overall standard error for effect size estimate
# P-value     - meta-analysis p-value
# Direction   - summary of effect direction for each study, with one '+' or '-' per study
# HetISq      - I^2 statistic which measures heterogeneity on scale of 0-100%
# HetChiSq    - chi-squared statistic in simple test of heterogeneity
# df          - degrees of freedom for heterogeneity statistic
# HetPVal     - P-value for heterogeneity statistic

