Michael S. Lawrence, Ph.D.

list of publications


1.  Johnston WK, Unrau PJ, Lawrence MS, Glasner ME, et al. (2001) "RNA-catalyzed RNA polymerization: accurate and general RNA-templated primer extension", Science 292:1319-25.

2.  Lawrence MS and Bartel DP (2003) "Processivity of ribozyme-catalyzed RNA polymerization", Biochemistry 42:8748-55.

3.  Lawrence MS and Bartel DP (2005) "New ligase-derived RNA polymerase ribozymes", RNA 11:1173-80.

4.  Lawrence MS, Phillips KJ and Liu DR (2007) "Supercharging proteins can impart unusual resilience", J Am Chem Soc 129:10110-2.

5.  The Cancer Genome Atlas Research Network (2008) "Comprehensive genomic characterization defines human glioblastoma genes and core pathways", Nature 455:1061-8.

6.  Ding L, Getz G, Wheeler DA, Mardis ER, et al. (2008) "Somatic mutations affect key pathways in lung adenocarcinoma", Nature 455:1069-75.

7.  Liu JM, Livny J, Lawrence MS, Kimball MD, et al. (2009) "Experimental discovery of sRNAs in Vibrio cholerae by direct cloning, 5S/tRNA depletion and parallel sequencing", Nucleic Acids Res 37:e46.

8.  Beroukhim R, Mermel CH, Porter D, Wei G, et al. (2010) "The landscape of somatic copy-number alteration across human cancers", Nature 463:899-905.

9.  Verhaak RG, Hoadley KA, Purdom E, Wang V, et al. (2010) "Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1", Cancer Cell 17:98-110.

10.  Bass AJ, Lawrence MS, Brace LE, Ramos AH, et al. (2011) "Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion", Nat Genet 43:964-8.

11.  Berger MF, Lawrence MS, Demichelis F, Drier Y, et al. (2011) "The genomic complexity of primary human prostate cancer", Nature 470:214-20.

12.  Brown JR, Lawrence MS, Hanna M, Tesar B, et al. (2011) "Novel Germline Genetic Variants Associated with Familial Chronic Lymphocytic Leukemia (CLL)", Blood 118:215-216.

13.  Chapman MA, Lawrence MS, Keats JJ, Cibulskis K, et al. (2011) "Initial genome sequencing and analysis of multiple myeloma", Nature 471:467-72.

14.  Hammerman PS, Sos ML, Ramos AH, Xu C, et al. (2011) "Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer", Cancer Discov 1:78-89.

15.  The Cancer Genome Atlas Research Network (2011) "Integrated genomic analyses of ovarian carcinoma", Nature 474:609-615.

16.  Stransky N, Egloff AM, Tward AD, Kostic AD, et al. (2011) "The mutational landscape of head and neck squamous cell carcinoma", Science 333:1157-60.

17.  Wang L, Lawrence MS, Wan Y, Stojanov P, et al. (2011) "SF3B1 and other novel cancer genes in chronic lymphocytic leukemia", N Engl J Med 365:2497-506.

18.  Banerji S, Cibulskis K, Rangel-Escareno C, Brown KK, et al. (2012) "Sequence analysis of mutations and translocations across breast cancer subtypes", Nature 486:405-9.

19.  Barbieri CE, Baca SC, Lawrence MS, Demichelis F, et al. (2012) "Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer", Nat Genet 44:685-9.

20.  Berger MF, Hodis E, Heffernan TP, Deribe YL, et al. (2012) "Melanoma genome sequencing reveals frequent PREX2 mutations", Nature 485:502-6.

21.  Greulich H, Kaplan B, Mertins P, Chen TH, et al. (2012) "Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2", Proc Natl Acad Sci U S A 109:14476-81.

22.  Hodis E, Watson IR, Kryukov GV, Arold ST, et al. (2012) "A landscape of driver mutations in melanoma", Cell 150:251-63.

23.  Imielinski M, Berger AH, Hammerman PS, Hernandez B, et al. (2012) "Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing", Cell 150:1107-20.

24.  Lee RS, Stewart C, Carter SL, Ambrogio L, et al. (2012) "A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers", J Clin Invest 122:2983-8.

25.  Lohr JG, Stojanov P, Lawrence MS, Auclair D, et al. (2012) "Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing", Proc Natl Acad Sci U S A 109:3879-84.

26.  Pugh TJ, Weeraratne SD, Archer TC, Pomeranz Krummel DA, et al. (2012) "Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations", Nature 488:106-10.

27.  Williams LJ, Tabbaa DG, Li N, Berlin AM, et al. (2012) "Paired-end sequencing of Fosmid libraries by Illumina", Genome Res 22:2241-9.

28.  Baca SC, Prandi D, Lawrence MS, Mosquera JM, et al. (2013) "Punctuated evolution of prostate cancer genomes", Cell 153:666-77.

29.  Cibulskis K, Lawrence MS, Carter SL, Sivachenko A, et al. (2013) "Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples", Nat Biotechnol 31:213-9.

30.  Cleary SP, Jeck WR, Zhao X, Chen K, et al. (2013) "Identification of driver genes in hepatocellular carcinoma by exome sequencing", Hepatology 58:1693-702.

31.  Drier Y, Lawrence MS, Carter SL, Stewart C, et al. (2013) "Somatic rearrangements across cancer reveal classes of samples with distinct patterns of DNA breakage and rearrangement-induced hypermutability", Genome Res 23:228-35.

32.  Dulak AM, Stojanov P, Peng S, Lawrence MS, et al. (2013) "Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity", Nat Genet 45:478-86.

33.  Francis JM, Kiezun A, Ramos AH, Serra S, et al. (2013) "Somatic mutation of CDKN1B in small intestine neuroendocrine tumors", Nat Genet 45:1483-6.

34.  Landau DA, Carter SL, Stojanov P, McKenna A, et al. (2013) "Evolution and impact of subclonal mutations in chronic lymphocytic leukemia", Cell 152:714-26.

35.  Lawrence MS, Stojanov P, Polak P, Kryukov GV, et al. (2013) "Mutational heterogeneity in cancer and the search for new cancer-associated genes", Nature 499:214-8.

36.  Pugh TJ, Morozova O, Attiyeh EF, Asgharzadeh S, et al. (2013) "The genetic landscape of high-risk neuroblastoma", Nat Genet 45:279-84.

37.  Ramkissoon LA, Horowitz PM, Craig JM, Ramkissoon SH, et al. (2013) "Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1", Proc Natl Acad Sci U S A 110:8188-93.

38.  Roberts SA, Lawrence MS, Klimczak LJ, Grimm SA, et al. (2013) "An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers", Nat Genet 45:970-6.

39.  Tamborero D, Gonzalez-Perez A, Perez-Llamas C, Deu-Pons J, et al. (2013) "Comprehensive identification of mutational cancer driver genes across 12 tumor types", Sci Rep 3:2650.

40.  Verhaak RG, Tamayo P, Yang JY, Hubbard D, et al. (2013) "Prognostically relevant gene signatures of high-grade serous ovarian carcinoma", J Clin Invest 123:517-25.

41.  Zack TI, Schumacher SE, Carter SL, Cherniack AD, et al. (2013) "Pan-cancer patterns of somatic copy number alteration", Nat Genet 45:1134-40.

42.  Brastianos PK, Taylor-Weiner A, Manley PE, Jones RT, et al. (2014) "Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas", Nat Genet 46:161-5.

43.  Brooks AN, Choi PS, de Waal L, Sharifnia T, et al. (2014) "A pan-cancer analysis of transcriptome changes associated with somatic mutations in U2AF1 reveals commonly altered splicing events", PLoS One 9:e87361.

44.  Cho J, Bass AJ, Lawrence MS, Cibulskis K, et al. (2014) "Colon cancer-derived oncogenic EGFR G724S mutant identified by whole genome sequence analysis is dependent on asymmetric dimerization and sensitive to cetuximab", Mol Cancer 13:141.

45.  Crompton BD, Stewart C, Taylor-Weiner A, Alexe G, et al. (2014) "The genomic landscape of pediatric Ewing sarcoma", Cancer Discov 4:1326-41.

46.  Giannakis M, Hodis E, Jasmine Mu X, Yamauchi M, et al. (2014) "RNF43 is frequently mutated in colorectal and endometrial cancers", Nat Genet 46:1264-6.

47.  Helman E, Lawrence MS, Stewart C, Sougnez C, et al. (2014) "Somatic retrotransposition in human cancer revealed by whole-genome and exome sequencing", Genome Res 24:1053-63.

48.  Kim Y, Hammerman PS, Kim J, Yoon JA, et al. (2014) "Integrative and comparative genomic analysis of lung squamous cell carcinomas in East Asian patients", J Clin Oncol 32:121-8.

49.  Landau DA, Stewart C, Reiter JG, Lawrence MS, et al. (2014) "Novel Putative Driver Gene Mutations in Chronic Lymphocytic Leukemia (CLL): Results from a Combined Analysis of Whole-Exome Sequencing of 262 Primary CLL Samples", Blood 124:1952-1952.

50.  Lawrence MS, Stojanov P, Mermel CH, Robinson JT, et al. (2014) "Discovery and saturation analysis of cancer genes across 21 tumour types", Nature 505:495-501.

51.  Lohr JG, Stojanov P, Carter SL, Cruz-Gordillo P, et al. (2014) "Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy", Cancer Cell 25:91-101.

52.  The Cancer Genome Atlas Research Network (2014) "Comprehensive molecular profiling of lung adenocarcinoma", Nature 511:543-550.

53.  The Cancer Genome Atlas Research Network (2014) "Integrated genomic characterization of papillary thyroid carcinoma", Cell 159:676-690.

54.  The Cancer Genome Atlas Research Network (2014) "Comprehensive molecular characterization of urothelial bladder carcinoma", Nature 507:315-322.

55.  Ojesina AI, Lichtenstein L, Freeman SS, Pedamallu CS, et al. (2014) "Landscape of genomic alterations in cervical carcinomas", Nature 506:371-5.

56.  Parfenov M, Pedamallu CS, Gehlenborg N, Freeman SS, et al. (2014) "Characterization of HPV and host genome interactions in primary head and neck cancers", Proc Natl Acad Sci U S A 111:15544-9.

57.  Perry JA, Kiezun A, Tonzi P, Van Allen EM, et al. (2014) "Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma", Proc Natl Acad Sci U S A 111:E5564-73.

58.  Polak P, Lawrence MS, Haugen E, Stoletzki N, et al. (2014) "Reduced local mutation density in regulatory DNA of cancer genomes is linked to DNA repair", Nat Biotechnol 32:71-5.

59.  Shankar GM, Taylor-Weiner A, Lelic N, Jones RT, et al. (2014) "Sporadic hemangioblastomas are characterized by cryptic VHL inactivation", Acta Neuropathol Commun 2:167.

60.  Van Allen EM, Mouw KW, Kim P, Iyer G, et al. (2014) "Somatic ERCC2 mutations correlate with cisplatin sensitivity in muscle-invasive urothelial carcinoma", Cancer Discov 4:1140-53.

61.  Van Allen EM, Wagle N, Stojanov P, Perrin DL, et al. (2014) "Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine", Nat Med 20:682-8.

62.  Wang L, Shalek AK, Lawrence MS, Ding R, et al. (2014) "Somatic mutation as a mechanism of Wnt/beta-catenin pathway activation in CLL", Blood 124:1089-98.

63.  Yuan Y, Van Allen EM, Omberg L, Wagle N, et al. (2014) "Assessing the clinical utility of cancer genomic and proteomic data across tumor types", Nat Biotechnol 32:644-52.

64.  Chung TK, Van Hummelen P, Chan PK, Cheung TH, et al. (2015) "Genomic aberrations in cervical adenocarcinomas in Hong Kong Chinese women", Int J Cancer 137:776-83.

65.  Horn H, Lawrence MS, Hu JX, Worstell E, et al. (2015) "A comparative analysis of network mutation burdens across 21 tumor types augments discovery from cancer genomes", bioRxiv 025445.

66.  Leiserson MD, Vandin F, Wu HT, Dobson JR, et al. (2015) "Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes", Nat Genet 47:106-14.

67.  Polak P, Karlic R, Koren A, Thurman R, et al. (2015) "Cell-of-origin chromatin organization shapes the mutational landscape of cancer", Nature 518:360-4.

68.  Ramos AH, Lichtenstein L, Gupta M, Lawrence MS, et al. (2015) "Oncotator: cancer variant annotation tool", Hum Mutat 36:E2423-9.

69.  Seiwert TY, Zuo Z, Keck MK, Khattri A, et al. (2015) "Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas", Clin Cancer Res 21:632-41.

70.  Stachler MD, Taylor-Weiner A, Peng S, McKenna A, et al. (2015) "Paired exome analysis of Barrett's esophagus and adenocarcinoma", Nat Genet 47:1047-55.

71.  van de Wetering M, Francies HE, Francis JM, Bounova G, et al. (2015) "Prospective derivation of a living organoid biobank of colorectal cancer patients", Cell 161:933-45.

72.  Haradhvala N, Polak P, et al., Lawrence MS and Getz G (2015) "Pervasive mutational strand asymmetries in cancer genomes reveal footprints of DNA damage and repair", submitted.