Michael S. Lawrence, Ph.D.
Group Leader, Computational Biology, Broad Institute Assistant Professor of Pathology, Harvard Medical School Assistant Geneticist, Massachusetts General Hospital Center for Cancer Research
Charlestown Navy Yard
Boston, MA 02129
lab webpage email CV
Human genomes, somatic DNA alterations, statistical analysis of mutations and mutational processes, DNA damage and repair, genomics-informed personalized medicine for cancer prevention, diagnosis, prognosis, and treatment.
Studying the highly complex patterns of mutational heterogeneity present throughout all levels of large cancer sequencing datasets.
Developing the MutSig software suite for statistical identification of significantly mutated genes against a highly complex mutational background.
Extracting novel insights from mutational strand asymmetries in cancer genomes, revealing which DNA damage and repair processes are associated with transcription and which are associated with replication.
