2020 Lab Ski Trip

(Coming soon!)

2019 Lab Ski Trip to Loon

2018 Lab Ski Trip to Loon

2017 Lab Ski Trip to Loon

Ice Castles!


On the cover of Cell...
Mutational Strand Asymmetry in Cancer


Seeking talented postdocs to join the team!

Job description

Michael S. Lawrence, Ph.D.
Group Leader, Computational Biology, Broad Institute
Assistant Professor of Pathology, Harvard Medical School
Assistant Geneticist, Massachusetts General Hospital
Center for Cancer Research
Charlestown Navy Yard
Boston, MA 02129

lab webpage

Human genomes, somatic DNA alterations, statistical analysis of mutations and mutational processes, DNA damage and repair, genomics-informed personalized medicine for cancer prevention, diagnosis, prognosis, and treatment.

  • Studying the highly complex patterns of mutational heterogeneity present throughout all levels of large cancer sequencing datasets.
  • Developing the MutSig software suite for statistical identification of significantly mutated genes against a highly complex mutational background.
  • Extracting novel insights from mutational strand asymmetries in cancer genomes, revealing which DNA damage and repair processes are associated with transcription and which are associated with replication.