2016 work_mode=on

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On the cover of Cell... Mutational Strand Asymmetry in Cancer

NOW HIRING! Seeking talented computational-minded biologists to join the team! Job description

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Michael S. Lawrence, Ph.D. Associate Member, Cancer Program, Broad Institute Associate Professor of Pathology, Harvard Medical School Associate Geneticist, Massachusetts General Hospital Center for Cancer Research Charlestown Navy Yard Boston, MA 02129 lab webpage email CV

Human genomes, somatic DNA alterations, statistical analysis of mutations and mutational processes, DNA damage and repair, genomics-informed personalized medicine for cancer prevention, diagnosis, prognosis, and treatment. Studying the highly complex patterns of mutational heterogeneity present throughout all levels of large cancer sequencing datasets. Developing the MutSig software suite for statistical identification of significantly mutated genes against a highly complex mutational background. Extracting novel insights from mutational strand asymmetries in cancer genomes, revealing which DNA damage and repair processes are associated with transcription and which are associated with replication. DrugMap: Quantitative pan-cancer analysis of cysteine ligandability TumorPortal: Genes, Cancers, DNA Mutations, & Annotations MutSig: algorithm for evaluating Mutation Significance Cancer genomes: discerning passengers from drivers Bringing out the usual—and unusual—cancer genomics suspects Broad's landmark study discovers new cancer genes Leading Genome Researchers Confident That the Cancer Puzzle Will Be Solved Thompson-Reuters: "The World's Most Influential Scientific Minds 2014" VIDEO:   The Spectra of Somatic Mutations Across Many Tumor Types    (YouTube) VIDEO:   In focus: Michael Lawrence